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Research ArticleExperimental Studies

In Vivo Effects of Afobazole (2-Mercaptobenzimidazole Derivative) on the 7,12-Dimethylbenz[α]anthracene-induced Oncogene and Suppressor Gene Expression

ISTVÁN SZANYI, LÁSZLÓ LUJBER, IMRE GERLINGER, JÓZSEF PYTEL, MIKLÓS BAUER, ANDRÁS CSEJTEY, ESZTER SZELE, KATALIN GOMBOS, ISTVÁN KISS, SERGEY SEREDENIN, MILADA YARKOVA and ISTVÁN EMBER
In Vivo November 2007, 21 (6) 1059-1063;
ISTVÁN SZANYI
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  • For correspondence: istvan.szanyi@aok.pte.hu
LÁSZLÓ LUJBER
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IMRE GERLINGER
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JÓZSEF PYTEL
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MIKLÓS BAUER
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ANDRÁS CSEJTEY
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ESZTER SZELE
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KATALIN GOMBOS
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ISTVÁN KISS
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SERGEY SEREDENIN
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MILADA YARKOVA
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ISTVÁN EMBER
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Abstract

Background: Afobazole, a new 2-mercaptobenzimidazole derivative, exhibited antimutagenic activity in chromosome aberration tests and antioxidant properties. The aim of this study was to demonstrate the potential chemopreventive effect of afobazole on the level of early biological effects by analysing changes in oncogene and tumor suppressor gene expression. Materials and Methods: Single intraperitoneal (i.p.) treatment with 7,12-dimethylbenz[α]anthracene (DMBA) combined with afobazole was administered to CBA/Ca (sensitive H-2K haplotype) female mice. The expression of Ha-ras and p53 was determined in the vital organs (liver, spleen, lung, kidney, thymus, lymph nodes and bone marrow) 24, 48 and 72 hours later. Results: Coadministration of afobazole and DMBA resulted in a decrease of DMBA-induced overexpression of Ha-ras and p53. Reduction of the DMBA-induced gene expression was most striking when afobazole was given in parallel with DMBA. Discussion: Our results strengthen the previous assumption, which was based on in vitro results, that afobazole has a chemopreventive effect in vivo.

  • Afobazole
  • 2-mercaptobenzimidazole
  • chemopreventive effect
  • oncogene
  • suppressor gene expression

Footnotes

  • Received June 20, 2007.
  • Revision received October 9, 2007.
  • Accepted October 17, 2007.
  • Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Vol. 21, Issue 6
November-December 2007
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In Vivo Effects of Afobazole (2-Mercaptobenzimidazole Derivative) on the 7,12-Dimethylbenz[α]anthracene-induced Oncogene and Suppressor Gene Expression
ISTVÁN SZANYI, LÁSZLÓ LUJBER, IMRE GERLINGER, JÓZSEF PYTEL, MIKLÓS BAUER, ANDRÁS CSEJTEY, ESZTER SZELE, KATALIN GOMBOS, ISTVÁN KISS, SERGEY SEREDENIN, MILADA YARKOVA, ISTVÁN EMBER
In Vivo Nov 2007, 21 (6) 1059-1063;

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In Vivo Effects of Afobazole (2-Mercaptobenzimidazole Derivative) on the 7,12-Dimethylbenz[α]anthracene-induced Oncogene and Suppressor Gene Expression
ISTVÁN SZANYI, LÁSZLÓ LUJBER, IMRE GERLINGER, JÓZSEF PYTEL, MIKLÓS BAUER, ANDRÁS CSEJTEY, ESZTER SZELE, KATALIN GOMBOS, ISTVÁN KISS, SERGEY SEREDENIN, MILADA YARKOVA, ISTVÁN EMBER
In Vivo Nov 2007, 21 (6) 1059-1063;
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