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Research ArticleExperimental Studies

Effects of Aucubin on the Healing of Oral Wounds

KYUNG MI SHIM, SEOK HWA CHOI, MOON-JIN JEONG and SEONG SOO KANG
In Vivo November 2007, 21 (6) 1037-1041;
KYUNG MI SHIM
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SEOK HWA CHOI
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MOON-JIN JEONG
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SEONG SOO KANG
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  • For correspondence: vetkang@chonnam.ac.kr
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Abstract

Aucubin is an iridoid glycoside with a variety of pharmacological effects, such as antimicrobial and anti-inflammatory, whilst also promoting dermal wound healing. This study examined the effects of 0.1% aucubin on oral wound healing. ICR male mice were divided into two groups: an untreated control group (n=18) and an aucubin-treated group (n=18). Saline or 0.1% aucubin solution was injected and artificial full thickness wounds were made on either side of the buccal mucosa. Specimens were taken on days 1, 3 and 5, and light microscopic examination and quantitative histological analysis were performed to determine the extent of re-epithelization, inflammatory cell infiltration and matrix formation. Re-epithelization and matrix formation of the aucubin-treated group occurred earlier than that of the control group. In addition, the number of inflammatory cells of the aucubin-treated group was fewer than that of the control group. In conclusion, aucubin may be useful for oral wound healing and can be applied as a topical agent to oral wounds.

  • Aucubin
  • oral mucosa
  • wound healing
  • mouse

Footnotes

    • Received June 4, 2007.
    • Revision received August 21, 2007.
    • Accepted August 30, 2007.
    • Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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    In Vivo: 21 (6)
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    Effects of Aucubin on the Healing of Oral Wounds
    KYUNG MI SHIM, SEOK HWA CHOI, MOON-JIN JEONG, SEONG SOO KANG
    In Vivo Nov 2007, 21 (6) 1037-1041;

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    Effects of Aucubin on the Healing of Oral Wounds
    KYUNG MI SHIM, SEOK HWA CHOI, MOON-JIN JEONG, SEONG SOO KANG
    In Vivo Nov 2007, 21 (6) 1037-1041;
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