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Research ArticleExperimental Studies

The (-590 C/T) Polymorphism in the Interleukin-4 Gene is Associated with Increased Risk for Early Stages of Corolectal Adenocarcinoma

ATHANASIOS YANNOPOULOS, NIKOLAOS NIKITEAS, AGAPI CHATZITHEOFYLAKTOU and CHRISTOS TSIGRIS
In Vivo November 2007, 21 (6) 1031-1035;
ATHANASIOS YANNOPOULOS
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NIKOLAOS NIKITEAS
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AGAPI CHATZITHEOFYLAKTOU
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CHRISTOS TSIGRIS
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  • For correspondence: ctsigkri@med.uoa.gr
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Abstract

Background: In the light of the known association between several carcinomas and the -590C/T polymorphism, which affects transcription of the antitumor interleukin-4 (IL-4) gene, the purpose of this study was to investigate the possible contribution of this polymorphism to the development of colorectal cancer. Materials and Methods: The -590C/T polymorphism was examined in DNA samples of 93 patients with colorectal cancer (adenocarcinomas) and 108 healthy controls of comparable ethnicity, age and gender. Results: The detected allele and carrier frequencies for the high expression T allele in the patient group were significantly decreased in comparison with that of the control group (13.44% versus 22.22%, and 21.51% versus 36.11%, respectively, p<0.01). The same pattern was observed between controls and patients in initial cancer stages. Conclusion: These findings indicate that IL-4 gene expression-related polymorphism is associated with the development of initial stages of colorectal cancer, while in advanced stages IL-4 levels appear to be less important.

  • Colorectal cancer
  • adenocarcinomas
  • interleukin-4
  • polymorphism
  • inflammation
  • angiogenesis
  • tumor growth
  • metastasis

Footnotes

  • Received July 12, 2007.
  • Revision received August 29, 2007.
  • Accepted October 1, 2007.
  • Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Vol. 21, Issue 6
November-December 2007
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The (-590 C/T) Polymorphism in the Interleukin-4 Gene is Associated with Increased Risk for Early Stages of Corolectal Adenocarcinoma
ATHANASIOS YANNOPOULOS, NIKOLAOS NIKITEAS, AGAPI CHATZITHEOFYLAKTOU, CHRISTOS TSIGRIS
In Vivo Nov 2007, 21 (6) 1031-1035;

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The (-590 C/T) Polymorphism in the Interleukin-4 Gene is Associated with Increased Risk for Early Stages of Corolectal Adenocarcinoma
ATHANASIOS YANNOPOULOS, NIKOLAOS NIKITEAS, AGAPI CHATZITHEOFYLAKTOU, CHRISTOS TSIGRIS
In Vivo Nov 2007, 21 (6) 1031-1035;
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