Abstract
The aim of this study was to investigate whether repeated exposure to radio frequency electromagnetic field (RF-EMF) of 1439 MHz affects the cerebral microcirculation, including blood-brain barrier function, in a rat brain. Materials and Methods: The head of the rat was exposed for four weeks (60 min/day, 5 days/week) to RF-EMF at 2.4 W/kg of brain averaged specific absorption rate (BASAR). Three microcirculatory parameters: blood-brain barrier permeability, leukocyte behavior and plasma velocity were measured before and after RF-EMF exposure using a closed cranial window method. Results: No extravasation of intravenously injected dyes from pial venules was found at any BASAR level. No significant changes in the number of endothelial-adhering leukocytes after exposure were found. The plasma velocity remained constant within the physiological range through each exposure. Conclusion: These findings suggest that there were no effects on the cerebral microcirculation under the given RF-EMF exposure conditions.
- Closed cranial window
- radio-frequency
- electromagnetic field
- blood-brain barrier
- leukocyte behavior
- cerebral microcirculation
- subchronic exposure
Footnotes
- Received January 10, 2007.
- Revision received March 20, 2007.
- Accepted March 28, 2007.
- Copyright © 2007 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved