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Review Article

Impairments of the 2-5A Synthetase/RNase L Pathway in Chronic Fatigue Syndrome

JO NIJS and KENNY DE MEIRLEIR
In Vivo November 2005, 19 (6) 1013-1021;
JO NIJS
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  • For correspondence: Jo.Nijs@vub.ac.be de.meirleir@telenet.be
KENNY DE MEIRLEIR
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  • For correspondence: Jo.Nijs@vub.ac.be de.meirleir@telenet.be
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Abstract

This paper provides an overview of the evidence addressing the impairments of the 2'-5' oligoadenylate (2-5 A) synthetase/RNase L pathway in Chronic Fatigue Syndrome (CFS) patients. The 2-5A synthetase/RNase L pathway in CFS patients appears to be both up-regulated (i.e. increased levels of bioactive 2-5A synthetase and increased activity of the RNase L enzyme) and deregulated (elastase and calpain initiate 83 kDa RNase L proteolysis, generating two major fragments with molecular masses of 37 and 30 kDa, respectively). The deregulation of the 2-5A synthetase/RNase L pathway in CFS accompanies decreased NK-function and deregulation of apoptotic pathways. Since various components of the pathway appear to be related to performance during a graded exercise stress test, some evidence supportive of the clinical importance of the impaired pathway in CFS patients has been provided. Studies addressing the treatment of the deregulation of the 2-5A synthetase/RNase L pathway in CFS are warranted.

  • Chronic fatigue syndrome
  • immunity
  • RNase L
  • review

Footnotes

  • Received May 27, 2005.
  • Accepted July 7, 2005.
  • Copyright © 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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In Vivo: 19 (6)
In Vivo
Vol. 19, Issue 6
November-December 2005
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Impairments of the 2-5A Synthetase/RNase L Pathway in Chronic Fatigue Syndrome
JO NIJS, KENNY DE MEIRLEIR
In Vivo Nov 2005, 19 (6) 1013-1021;

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Impairments of the 2-5A Synthetase/RNase L Pathway in Chronic Fatigue Syndrome
JO NIJS, KENNY DE MEIRLEIR
In Vivo Nov 2005, 19 (6) 1013-1021;
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