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Research Article

Inhibition of Branching Morphogenesis of Mouse Fetal Submandibular Gland by Sodium Fluoride - Protection by Epidermal Growth Factor

TAKAHIRO NAKA, SHICHIRO MARUYAMA, TAKAHIDE NAGAO, FUMITOSHI TAKAYAMA, JUN MAKI, TOSHIKAZU YASUI, HIROSHI SAKAGAMI and SHUJI OHKAWA
In Vivo March 2005, 19 (2) 327-334;
TAKAHIRO NAKA
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SHICHIRO MARUYAMA
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TAKAHIDE NAGAO
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FUMITOSHI TAKAYAMA
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JUN MAKI
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TOSHIKAZU YASUI
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HIROSHI SAKAGAMI
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  • For correspondence: sakagami@dent.meikai.ac.jp
SHUJI OHKAWA
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Abstract

As an initial step to study the effect of sodium fluoride on the oral environment, we investigated how sodium fluoride (NaF) affects the branching morphogenesis of fetal mouse submandibular gland (SMG). When mouse SMG was prepared from the embryo at 13 days post prenatal stage and cultured, gradual development of branching morphogenesis was observed. Addition of NaF affected this morphological change in bimodal fashions. At a lower concentration of NaF (<2 μM), the branching morphogenesis was slightly enhanced, whereas at a higher concentration of NaF (4~8μM), it was almost completely inhibited. The inhibitory effect of NaF at the higher concentration was abrogated by stimultaneous addition of epidermal growth factor (EGF), but not by 5α-dihydrotestosterone (DHT) or insulin-like growth factor (IGF). These data demonstrate that EGF can effectively reduce the cytotoxic activity of NaF at micromolar concentration.

Keywords:
  • Sodium fluoride
  • mouse submandibular gland
  • branching morphogenesis
  • EGF
  • IGF
  • DHT

Footnotes

    • Received September 15, 2004.
    • Accepted January 20, 2005.
  • Copyright © 2005 International Institute of Anticaner Research (Dr. John G. Delinassios), All rights reserved
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Vol. 19, Issue 2
March-April 2005
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Inhibition of Branching Morphogenesis of Mouse Fetal Submandibular Gland by Sodium Fluoride - Protection by Epidermal Growth Factor
TAKAHIRO NAKA, SHICHIRO MARUYAMA, TAKAHIDE NAGAO, FUMITOSHI TAKAYAMA, JUN MAKI, TOSHIKAZU YASUI, HIROSHI SAKAGAMI, SHUJI OHKAWA
In Vivo Mar 2005, 19 (2) 327-334;

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Inhibition of Branching Morphogenesis of Mouse Fetal Submandibular Gland by Sodium Fluoride - Protection by Epidermal Growth Factor
TAKAHIRO NAKA, SHICHIRO MARUYAMA, TAKAHIDE NAGAO, FUMITOSHI TAKAYAMA, JUN MAKI, TOSHIKAZU YASUI, HIROSHI SAKAGAMI, SHUJI OHKAWA
In Vivo Mar 2005, 19 (2) 327-334;
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