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Research Article

Synergistic Antiproliferative Action of the Flavonols Quercetin and Kaempferol in Cultured Human Cancer Cell Lines

MARGARET LEIGH ACKLAND, SIMONE VAN DE WAARSENBURG and ROD JONES
In Vivo January 2005, 19 (1) 69-76;
MARGARET LEIGH ACKLAND
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  • For correspondence: leigha@deakin.edu.au
SIMONE VAN DE WAARSENBURG
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ROD JONES
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Abstract

The consumption of vegetables containing the flavonols quercetin and kaempferol reduces the risk of cancer. We utilized human gut (HuTu-80 and Caco-2) and breast cancer cells (PMC42) to show the synergistic effect of quercetin and kaempferol in reducing cell proliferation. A trend in reduction of total cell counts was seen following a single exposure, a 4-day exposure or a 14-day exposure to quercetin and kaempferol. Combined treatments with quercetin and kaempferol were more effective than the additive effects of each flavonol. The reduction in cell proliferation was associated with decreased expression of nuclear proliferation antigen Ki67 and decreased total protein levels in treated cells relative to controls. In conclusion, the synergistic antiproliferative effect of quercetin and kaempferol demonstrated in cultured human cells has broad implications for understanding the influence of dietary nutrients in vivo, where anticancer effects may be a result of nutrients which act in concert.

  • Anticancer effects
  • flavonols
  • human cells

Footnotes

    • Received September 17, 2004.
    • Accepted December 20, 2004.
  • Copyright © 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Vol. 19, Issue 1
January-February 2005
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Synergistic Antiproliferative Action of the Flavonols Quercetin and Kaempferol in Cultured Human Cancer Cell Lines
MARGARET LEIGH ACKLAND, SIMONE VAN DE WAARSENBURG, ROD JONES
In Vivo Jan 2005, 19 (1) 69-76;

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Synergistic Antiproliferative Action of the Flavonols Quercetin and Kaempferol in Cultured Human Cancer Cell Lines
MARGARET LEIGH ACKLAND, SIMONE VAN DE WAARSENBURG, ROD JONES
In Vivo Jan 2005, 19 (1) 69-76;
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