Abstract
Experiments in vitro have shown that dehydroascorbic acid (DHA) possesses antitumor properties under irradiation, which are gradually enhanced by combination with β-carotene or vitamin E. On the other hand the cytostatic efficiency of mitomycin C (MMC) is increased from ΔD37 = -93 up to ΔD37 = -141 in the presence of DHA. It has also been shown that Escherichia coli bacteria are able, to some extent, to reduce DHA to ascorbate under the same experimental conditions. The results are of interest for the radiation therapy of cancer.
Footnotes
- Received April 30, 2004.
- Accepted October 14, 2004.
- Copyright © 2004 The Author(s). Published by the International Institute of Anticancer Research.
