Influence of Fluticasone Propionate on the Production of Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor from Nasal Fibroblasts In Vitro

Abstract

The influence of fluticasone propionate (FP) on vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) production from nasal polyp fibroblasts (NPFs) was examined in vitro. NPFs, at a density of 2.5 × 10⁵ cells/ml, were stimulated with 25 ng/ml TNF-α in the presence or absence of FP for 24 h. FP at more than 10^-6 M could suppress VEGF production from NPFs. bFGF production induced by TNF-α stimulation was also suppressed by FP, when the agent was added to cell cultures at more than 10^-7 M. The present results also showed the suppressive activity of FP on mRNA expression for VEGF and bFGF, which were increased by TNF-α stimulation.