Abstract
Bone is a highly innervated tissue consisting of nerve fibers, which contain many neurotransmitters including glutamate. Recently, a number of studies have identified functional glutamate receptors in osteoblasts and osteoclasts, implying that the glutamatergic system has an apparent regulatory role in bone physiology. This review outlines the evidence which suggest that the glutamatergic system regulates bone physiology.
Footnotes
- Received March 11, 2004.
- Accepted June 8, 2004.
- Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved