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Research Article

IgM Serum Antibodies to Epstein-Barr Virus are Uniquely Present in a Subset of Patients with the Chronic Fatigue Syndrome

A. MARTIN LERNER, SAFEDIN H. BEQAJ, ROBERT G. DEETER and JAMES T. FITZGERALD
In Vivo March 2004, 18 (2) 101-106;
A. MARTIN LERNER
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SAFEDIN H. BEQAJ
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ROBERT G. DEETER
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JAMES T. FITZGERALD
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Abstract

Background: A unique subset of patients with chronic fatigue syndrome (CFS) and IgM serum antibodies to cytomegalovirus (HCMV) non-structural gene products p52 and CM2 (UL 44 and UL 57) has been described. Patients and Methods: Fifty-eight CFS patients and 68 non-CFS matched controls were studied. Serum antibodies to EBV viral capsid antigen (VCA) IgM and EBV Early Antigen, diffuse (EA, D) as well HVCMV(V), IgM and IgG; VP (sucrose, density purified V); p52 and CM2 IgM serum antibodies were assayed. Results: Mean age of CFS patients was 44 years (75% women). Control patients were 9 years older (73% women). Serum EBV VCA IgM positive antibody titers were identified in 33 CFS patients (Group A subset EBV VCA IgM 62.3±8.3, neg.<20), but were not present in other CFS patients, (Group B subset EBV VCA IgM 6.8±0.7) controls (p<0.0001). EBV VCA IgM titers remained positive in CFS patients from Group A for 24-42 months. Conclusion: Serum antibody to EBV VCA IgM may be a specific diagnostic test for a second subset of CFS patients.

Footnotes

    • Received November 26, 2003.
    • Accepted January 5, 2004.
  • Copyright © 2004 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved
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Vol. 18, Issue 2
March-April 2004
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IgM Serum Antibodies to Epstein-Barr Virus are Uniquely Present in a Subset of Patients with the Chronic Fatigue Syndrome
A. MARTIN LERNER, SAFEDIN H. BEQAJ, ROBERT G. DEETER, JAMES T. FITZGERALD
In Vivo Mar 2004, 18 (2) 101-106;

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IgM Serum Antibodies to Epstein-Barr Virus are Uniquely Present in a Subset of Patients with the Chronic Fatigue Syndrome
A. MARTIN LERNER, SAFEDIN H. BEQAJ, ROBERT G. DEETER, JAMES T. FITZGERALD
In Vivo Mar 2004, 18 (2) 101-106;
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  • Detection of Herpesviruses and Parvovirus B19 in Gastric and Intestinal Mucosa of Chronic Fatigue Syndrome Patients
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