Abstract
Background/Aim: Non-melanoma skin cancers (NMSC) are the most common neoplasms worldwide and their incidence has been proven to increase in recent years and their treatment should aim at cancer cure as well as cosmetic and functional results. The aim of the study was to report the results of our mono-institutional series of high-dose-rate radiotherapy (cHDR-RT) in NMSC, based on a homogenous technique and two different treatment schedules. Patients and Methods: All patients affected by NMSC who were consecutively evaluated and treated at our Interventional Oncology Center from October 2018 to August 2020, were included. Patients underwent cHDR-RT using flap applicators and remotely afterloaded Ir-192 sources. Results: Overall, 51 patients were treated for a total of 67 lesions. Local control (LC) and disease-specific survival (DSS) were 94.0% and 100%, respectively. Grade 1, grade 2, grade 3 and grade 4 acute toxicity rates were 24.6%, 3.5%, 3.5%, and 0.0%, respectively. The cosmetic results were graded as excellent/good, fair, and poor in 73.7%, 19.3%, and 7.0%. Conclusion: cHDR-RT of NMSC is an effective alternative to surgery due to excellent outcomes both in terms of local control and aesthetic results especially in the face.
Non-melanoma skin cancers (NMSC) are the most common neoplasms worldwide and their incidence has been proven to increase in the recent years (1). The two most frequent NMSC are squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). Albeit with a better prognosis than other cancers, the NMSC treatment strategies should be properly selected considering the possible negative impact on quality of life of suboptimal cosmetic results (2). Therefore, treatment of NMSC should aim at cancer cure as well as cosmetic and functional results (3). Therapeutic options include surgery, radiotherapy (RT), and topical agents. More recently for locally advanced or metastatic tumors where curative surgery and curative radiotherapy are not feasible, systemic agents such as hedgehog pathway inhibitors for BCC and immune checkpoint inhibitors for SCC are proposed (4, 5). RT is generally indicated in the following situations: i) exclusive therapy of tumors in anatomical sites where surgical excision might have a poor cosmetic outcome; ii) adjuvant treatment in case of positive surgical margins or high risk of recurrence (4-6).
There is a large number of clinical studies on RT of NMSC. However, most evidence come from retrospective series (7, 8) and the efficacy of contact high-dose-rate radiotherapy (cHDR-RT, brachytherapy) should be better investigated especially in terms of optimal treatment schedules and techniques. Therefore, the aim of this study was to report the results of our mono-institutional series of HDR contact radiotherapy in NMSC, based on a homogenous technique (flap applicators) and two different treatment schedules.
Patients and Methods
All NMSC patients treated at our Interventional Oncology Center (IOC) (9) with cHDR-RT based on flap applicators and remote afterloaded Ir-192 sources were considered.
Eligibility criteria were as follows: patients with NMSC without infiltration of deep structures. Histological confirmation was always performed except in cases of clinically relevant risk (e.g., elderly patients on anticoagulation therapy) or expected cosmetic sequelae or in case of patient refusal. For lesions with high-risk clinical features (thickness >4 mm or diameter >20 mm) or histological high-risk features (deep dermal and/or perineural and/or lymphovascular invasion and/or moderate/poor differentiation) an additional imaging evaluation (Ultra Sound, Computed Tomography or Magnetic Resonance) was required according to primary site and related lymph node drainage (10). Exclusion criteria were as follows: advanced tumors with deep ulcer or deep dermis infiltration, and prior RT on the same anatomical site. Data were retrospectively extracted within the frame of the SKIN-COBRA (Consortium for Brachytherapy data Analysis) system (11).
Fifty-one patients were identified and therefore included in the present report. All patients were evaluated by the institutional Skin-Cancer Multidisciplinary Tumour Board (S-MDTB) and underwent a complete physical examination and a comprehensive clinical evaluation by a board of dermatologists experienced in skin cancers who had ruled out the feasibility or appropriateness of surgical resection or other local treatments.
The gross tumor volume (GTV) was jointly identified by dermatologists and radiation oncologists using dermatoscopy. The clinical target volume (CTV) was defined by adding to the GTV an additional margin of 5-10 mm or 10-20 mm in patients with BCC and SCC, respectively.
The dose prescription point was at 3-5 mm under the skin surface based on the Groupe Européen de Curiethérapie (GEC) and the European Society for Radiotherapy & Oncology (ESTRO) recommendations. In case of advanced tumors with deep ulcer or deep dermis infiltration, patients underwent interstitial interventional or external beam radiotherapy and therefore were excluded from this analysis. Flap applicators, either directly tailored to the target surface or attached to a customized thermoplastic mask, were used according to the anatomic site. However, in all cases a bolus was used to cover the flap and to ensure the backscattering according to the TG-43 calculation (12, 13).
Two different fractionation schedules were used: 40 Gy, 5 Gy/fraction, bis in die (BID) schedule (with a time interval >6 h) or 54 Gy, 3 Gy/fraction, 3 days/week regimen, based on patients’ compliance and preference (14). Acute and late toxicity was assessed using the Radiation Therapy Oncology Group (RTOG) and the RTOG/European Organization for Research and Treatment of Cancer (EORTC) criteria (15). The cosmetic assessment was performed using a simplified three-point scale: 1 – Excellent/Good, 2 – Fair, and 3 – Poor. Both toxicity and cosmetic assessment were regularly recorded during each follow-up visit and jointly graded by a radiation oncologist and a dermatologist. Since high quality digital images of the treated area were acquired and stored during all visits, both the toxicity grade and the cosmetic assessment were subsequently confirmed through retrospective analysis of all pictures by the multidisciplinary board. Actuarial local control (LC), overall survival (OS), and disease-specific survival (DSS) were calculated using the Kaplan-Meier method.
Results
Overall, 67 skin lesions of 51 patients were treated between October 2018 and August 2020. Median patient age was 77 years (range=52-97) with a male prevalence (male/female ratio: 39/12). Twenty-two lesions (32.8%) were SCC and 39 lesions (58.2%) were BCC, while 6 lesions (9.0%) were basosquamous carcinoma. Patient characteristics are reported in Table I. Fifty-three lesions (79.1%) were on the face. More specifically, 19 lesions (28.4%) were on the nose, 15 (22.4%) in the scalp region, 7 lesions (10.4%) were located on the ear, 5 (7.5%) involved eyelids and/or periorbital region and 4 (6.0%) were in the cheek. Table II shows the list of all treated sites.
Sixty-two out of 67 (93%) lesions were treated as the exclusive therapy and five (7%) in the adjuvant setting (in all cases due to positive surgical margins). Moreover, 27 lesions (39.1%) were treated using the 40 Gy, 5 Gy/fraction, BID schedule (with a time interval >6 hours) while 40 lesions (60.9%) underwent the 54 Gy, 3 Gy/die, 3 days/week regimen. Median follow-up was 10 months (range=6-27 months). Two-year LC, calculated on a per patient basis was 94.0% (93.5% in the definitive and 100% in the adjuvant setting). Two-year OS and DSS were 90.2% and 100%, respectively. Kaplan-Meier curves are shown in Figure 1A and B. Acute Grade 1 (G1), grade 2 (G2), grade (G3), and grade (G4) toxicity was recorded in 24.6%, 3.5%, 3.5%, and 0.0% of lesions, respectively. In 68.4% of all treated lesions no acute toxicity was observed. Regarding late toxicity, only some few cases of chronic ulceration were recorded. However, these sequelae have only been observed in lesions already ulcerated before treatment.
In terms of cosmetic assessment, the result was scored as Excellent/Good in 73.7% of treated lesions and as Fair in 19.3% of them. Moreover, the cosmetic result was scored as Poor in only 7.0% of treated lesions (3.5% were on the scalp and 3.5% on the leg).
Discussion
The two-year outcomes of our study are very encouraging and confirm the results of previous analyses reporting favorable outcomes after cHDR-RT of NMSC (16). More generally, ours and other reports show that cHDR-RT represents an effective and safe therapeutic option for NMSCs, as confirmed by their inclusion in several international guidelines published in recent years (17-18). Moreover, some literature reviews confirmed that cHDR-RT is effective in NMSC treatment, with around 97% local control rate and 94.8% excellent or good cosmetic results even in elderly patients (19, 20).
Regarding toxicity, it is noteworthy that, in our study, no acute toxicity was recorded in 68.0% of treated lesions and G3 acute toxicity rate was only 3.0%. These results confirm the safety of cHDR-RT in the treatment of NMSC. In fact, in a recent report, 90% of patients experienced dermatitis but without any case of >G3 toxicity. Moreover, all acute toxic events recovered between the first and the second month after treatment end (21). In another report, the most common acute toxicities were itch (42.0%), pain (23.0%), xerosis (12.0%), and alopecia (12.0%). The authors recorded only G1 late toxicities including hypopigmentation (15.4%), itch (8.0%), mild erythema (7.0%), and telangiectasia (7.0%) (16). In another series late toxicities were even lower including erythema (4.4%), chronic ulceration (4.0%), telangiectasia (2.6%), and pigmentation changes (2.2%) (22). However, particular caution should be addressed to those rare cases with factors able to prolong healing such as very large and ulcerated lesions, poorly vascularization sites, areas with frequent traumas (usually the lower extremities), or patients with vascular disorders (typically diabetes). In fact, in these cases, also chronic ulcerations may occur (23, 24).
Furthermore, additional considerations concerning the advantages of interventional radiotherapy (interstitial) in mucosal midface SCCs arising at the junction with skin surfaces, typically at the level of the lips, buccal mucosa and nose vestibule, also fully apply to NMSC arising in the same area and treated by cHDR-RT (25, 26). In fact, surgical reconstruction of these areas, and in particular of the nose tip, is notoriously extremely difficult because of the exposure and the high aesthetic impact of minimal imperfections on one hand, and of the extremely complex pattern of relieves and hollows created by the nose cartilage and underlying maxillary and nasal bones, on the other. Therefore, preservation of the osteocartilaginous framework, which is pretty resistant to radiation, by cHDR-RT, is the most successful therapeutic option in midface malignancies from functional and aesthetic points of view (27).
There is evidence in the literature, coming also from prospective studies, that hypofractionated regimens are equivalent to more protracted schedules in terms of local control (26). However, protracted schedules have the benefit of lower acute and late toxicities and better cosmetic outcomes (28, 29). In particular some authors suggested the limit of 3 Gy per fraction as the maximum acceptable cut-off to achieve the better safety and cosmetic results (30). Nevertheless, our study showed excellent results in terms of cosmetics and toxicity even though over 40% of lesions were treated with a hypofractionated-accelerated regimen.
cHDR-RT seems particularly advantageous in some specific settings. First of all, it offers clear advantages in anatomical sites where organs at risk are very close to the target such as the eyelids, as shown by a systematic review about this topic (31). In particular, when dealing with eyelid NMSC, it is advisable to use ocular shields to further reduce the amount of dose reaching the eye (32). More generally, facial lesions are probably the most suitable for cHDR-RT being usually located on curved surface and near to organs at risk (33, 34). Secondly, cHDR-RT is particularly useful and safe in older patients and the slight difference between OS and DSS registered in our study confirms such results because no patients died of NMSC but a few died of concomitant diseases. Finally, it should be noted that, due to the reduction in the number of fractions, c-HDR-RT is particularly useful in the present COVID-19 era while reducing the number of hospital visits (35).
Despite the aforementioned advantages, especially in some settings, it should be noted that cHDR-RT has a limited spread in the clinical practice across the different countries (36, 37). However, it is interesting to note the actual trend on the use of cHDR-RT in NMSC, showing a renewed interest (38). In particular, cHDR-RT has been demonstrated to be a valid therapeutic option especially in cases of extreme stress for the health systems (39).
The results of a recent survey in North American and European centers confirmed that cHDR-RT holds a huge potential given that it allows a convenient and safe treatment of NMSC. Two interesting findings of that survey were the routine estimation of lesions depth via ultrasound before treatment start, by about 60% of the responders, and a trend towards increased number of fractions for larger targets. However, an important highlighted limitation was the significant variation in the pattern of care, especially regarding planning parameters used to evaluate and compare different treatment plans (40).
In a previous survey performed across Canadian Centers, the most frequently reported reasons to choose cHDR-RT over external beam RT were the irregular lesions shape, tumor located on curved surfaces or close to organs at risk, or very small lesion size making impractical the latter technique. The only absolute contraindication to cHDR-RT was the lesion depth (no more than 5 mm) while, on the contrary, tumor size, lymphatic invasion, vascular invasion, grade of differentiation, histologic subtype, and previous topical therapy were not considered as contraindications (41).
Considering the recent success achieved with anticancer immunotherapies including immune checkpoint inhibitors, the combination of cHDR-RT and immunotherapy has emerged as an exciting field of research with the potential for significant clinical benefit (42).
Regarding the limitations of the results presented in this study some relevant considerations need to be addressed. First, the retrospective design, potentially leading to selection and evaluation bias. However, it should be considered that data were collected prospectively, and that all evaluations (local control, toxicity, cosmetics) were performed in a multidisciplinary setting and subjected to an independent check by the tumor board. Another limitation is represented by the small sample size, which has prevented a thorough subgroup analysis based on setting and treatment regimen. Finally, our positive results were recorded in a highly selected patient population treated in a multidisciplinary setting. Therefore, our findings cannot be generalized to more advanced NMSC patients or to Centers where patients are not managed by a multidisciplinary team.
Despite these limitations, our study confirms the optimal results in terms of tumor control, cosmetics, and tolerability of cHDR-RT in NMSC. These results justify further trials aimed to define: i) the optimal radiotherapy regimen, in terms of dose and fractionation, according to setting and tumor characteristics; ii) the optimal criteria for the selection of patients to be referred to cHDR-RT. These studies could be based on the development of predictive models based on large databases aimed to improve treatment quality and efficacy, considering the high number of available clinical, molecular, and genetic parameters, and the limits in our cognitive abilities in integrating more than few variables (43). For these reasons, a GEC-ESTRO H&N and Skin Working Group project was recently activated (11).
Conclusion
The results of this study, performed through close medical interdisciplinary collaboration, confirm the efficacy and safety of c-HDR-RT and the importance of a multidisciplinary approach in NMSC management. Based on these results, cHDR-RT should be considered especially in anatomical regions where the cosmetic result is of paramount importance such as the face. In fact, quality of life represents an important issue in patients with skin cancers and the role of dermato-oncology is central to improve patient care and outcomes especially when the management is performed in a dedicated multidisciplinary team.
Footnotes
Authors’ Contributions
Luca Tagliaferri: Conception of the work; Alessandro Di Stefani: Conception of the work; Francesco Bussu: Conception of the work; Elisa Placidi: Analysis of data for the work; Nikola Dino Capocchiano: Interpretation of data for the work; Francesco Giuseppe Ciardo: Acquisition of data for the work; Calogero Casà: Acquisition of data for the work; Bruno Fionda: Drafting of the work; Valentina Lancellotta: Drafting of the work; Gabriella Macchia: Drafting of the work; Alessio Giuseppe Morganti: Final approval of the version to be published; György Kovács: Final approval of the version to be published; Ketty Peris: Final approval of the version to be published; Vincenzo Valentini: Final approval of the version to be published.
This article is freely accessible online.
Conflicts of Interest
The Authors declare no conflicts of interest.
- Received April 19, 2021.
- Revision received May 11, 2021.
- Accepted May 21, 2021.
- Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved